My grandma had it for many years before she passed away. She had enough vision to function until the end, but it did slowly worse and worse until her vision was extremely impaired. But she never went completely blind. She passed away about a decade ago at age 94, and she suffered with MD for 15 or 20 years before that. Hopefully the medicine had made advances in the past decade, and your wife will have a better time of it than Grandma.