Oh yeah, not the least of which is Israel and her future survival, but the Dear Leader already doesn't care about that and is actively undermining the only ally we ever had in the entire region. And I do not count the Saudi's or the rest of the temporarily oil rich Gulf states, they are temporary/limited use allies...once their wells go dry that relationship is dead, besides most of them would be natural enemies if nature took a true course. And I don't count Turkey, who under that lunatic Erdogan wants to become another Iran or Syria without the backward economy or being a Russian vassal. And if Syria becomes nothing but another Russian province in all but name, then any place in the area can suffer the same fate...just like anybody in the Ukraine region can be at risk of being annexed. How equipped is Romania or Hungary to resist an incursion?
If history shows anything it shows leadership vacuums of this scale don't just vaporize into nothing...those with the appetite come rushing in.
I would expect China and possibly the Norks to start getting more aggressive too, the ChiComs are busy with infrastructure expansion projects along with their military expansion efforts, sooner rather than later they will look to exercise them.
But one cannot say Obama isn't executing his vision perfectly...he wanted to reduce America's influence in the world and he is succeeding beyond comprehension.
Things are going to get much much worse.